From a Single Breakthrough to a Pipeline of Possibility.
Addressing a wide range of gastrointestinal conditions starting with Short Bowel Syndrome (SBS) and expanding across the entire GI tract.
Expanding What’s Possible in GI Intervention.
Eclipse Regenesis was founded to solve one of the most urgent challenges in pediatric care, Short Bowel Syndrome (SBS). But the same approach we’re using to stimulate safe, controlled intestinal regeneration also applies to a broader set of GI conditions where healing is currently limited, and long-term solutions are few.
We’re exploring applications across the GI tract, including ulcer closure, stent anchoring, and post-resection recovery, with the goal of helping more patients restore function and independence.
Distraction Enterogenesis
Tissue Approximation
Anchoring
Device-based mechanical lengthening of GI tissues.
Used to stimulate controlled tissue growth in the esophagus, small intestine, colon, and rectum.
Plication-based closure of tissue edges for healing.
Ideal for use after endoscopic mucosal resection (EMR), ulcer closure, or post-resection support.
Reversible mechanical hold to support GI hardware.
Used to anchor stents, coils, and other devices by temporarily engaging surrounding tissue.
A Unified Mechanism for Multiple GI Challenges.
Our proven results are based on the principles of distraction enterogenesis and tissue approximation – biologically driven processes that stimulate regeneration, closure, or structural reinforcement. These mechanisms apply across multiple areas of the GI tract, enabling scalable innovation from a single core technology.
Below are key areas of clinical interest under evaluation.
Small Intestine (Primary Focus)
- Short Bowel Syndrome (lengthening/stimulation — core clinical trial focus)
- Ulcer/Perforation Closure (post-EMR healing support)
- Duodenal Stent Anchoring
Rectum
- Rectal Cancer (closure after excision, lengthening to support reconstruction)
Large Intestine
- Colon Polyp Removal (tissue approximation)
- Colon Cancer (post-resection tissue closure / potential lengthening)
- Colon Lengthening (post-cancer/disease, especially in pediatric patients)
Esophagus
- Barrett’s Esophagus (tissue closure post-cancer resection / EMR)
- Esophageal Stent Anchoring
Interested in Partnering on Future Applications?
If you’re a clinician, researcher, or MedTech innovator with interest in tissue regeneration, stent anchoring, or post-resection recovery, we’d love to connect. Let’s shape the future of gastrointestinal care together.